Regulation of endothelial hemoglobin alpha expression by Kruppel-like factors
نویسندگان
چکیده
منابع مشابه
Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
Krüppel-like factor (KLF) family members share a three C2H2 zinc finger DNA binding domain, and are involved in cell proliferation and differentiation control in normal as in pathological situations. Studies over the past several years support a significant role for this family of transcription factors in carcinogenesis. KLFs can both activate and repress genes that participate in cell-cycle re...
متن کاملEndothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.
Antiphospholipid syndrome is characterized by thrombosis and/or recurrent pregnancy loss in the presence of antiphospholipid antibodies (APLAs). The majority of APLAs are directed against phospholipid-binding proteins, particularly β₂-glycoprotein I (β₂GPI). Anti-β₂GPI antibodies activate endothelial cells in a β₂GPI-dependent manner through a pathway that involves NF-κB. Krüppel-like factors (...
متن کاملAlterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.
Erythroid Krüppel-like factor (EKLF) is an erythroid zinc finger protein identified by its interaction with a CACCC sequence in the beta-globin promoter, where it establishes local chromatin structure permitting beta-globin gene transcription. We sought to identify other EKLF target genes and determine the chromatin status of these genes in the presence and absence of EKLF. We identified alpha ...
متن کاملRegulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4.
Type I cGMP-dependent protein kinase (PKG I) plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, but little is known about the regulation of PKG I expression in smooth muscle cells. We found opposing effects of RhoA and Rac1 on cellular PKG I expression: (i) cell density-dependent changes in PKG I expression varied directly with Rac1 act...
متن کاملSite-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.
OBJECTIVE Endothelial transcription factors Krüppel-like factor 4 (KLF4) and KLF2 are implicated in protection against atherogenesis. Steady-state microRNA (miR) regulation of KLFs in vivo is accessible by screening region-specific endothelial miRs and their targets. METHODS AND RESULTS A subset of differentially expressed endothelial miRs was identified in atherosusceptible versus protected ...
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ژورنال
عنوان ژورنال: Vascular Medicine
سال: 2017
ISSN: 1358-863X,1477-0377
DOI: 10.1177/1358863x17722211